Despite nearly securing a draw in the first leg, PSV ended up being defeated by Juventus for the second time within five months. Ivan Perisic scored an equalizer, becoming the oldest player to score for the club in either the Champions League or the European Cup. However, this goal wasn't enough to prevent the loss.

In the 82nd minute, Juventus substitute Samuel Mbangula scored, dashing the hopes of the Dutch champions. As a result, PSV now has a one - goal deficit to overcome in the midweek encounter.

PSV's recent record in UEFA's top - tier competition isn't in their favor. Since eliminating Arsenal in 2007, they haven't won a knockout tie. After losing the first leg in 11 such instances, they've only managed to progress on three occasions.

Nevertheless, on their home ground, they have an impressive 12 - game unbeaten streak in European competitions. This includes victories in their last three matches against Girona, Shakhtar Donetsk, and Liverpool.

Peter Bosz has witnessed his team's inability to replicate last season's outstanding domestic form. In their last outing, they needed a stoppage - time goal from Isaac Babadi to salvage a point against Utrecht.

Having relinquished the top spot to their long - standing rivals Ajax, second - placed PSV has managed just two wins from their last eight Eredivisie fixtures. This marks the club's worst start to a calendar year since 1980.

With a place in the Champions League's last 16 at stake, Bosz will be hoping that all these struggles can be put aside on Wednesday night when they host Juventus at the Philips Stadion for the first time.

Undefeated there since November 2022, PSV last failed to score in a home game over two years ago, so they will expect to push Juve all the way.

After Weston McKennie's blockbuster set them on the path to victory last week, Juventus now head for the Netherlands having drawn each of their last three Champions League away games - another stalemate would now see them through.

The Italian giants kicked off their league-phase campaign with a 3-1 home win over PSV, when McKennie was also on target, but they went on to limp home in 20th position - two points and six places behind their Dutch rivals.

Yet, history suggests Juve can now make it three wins from three, as they have progressed from their last 20 European Cup or Champions League knockout stage ties when winning the first leg - a run which dates back to 1979.

Recently, the revived Bianconeri have risen out of a mid-season malaise that featured just one success in eight games, winning four on the spin over the past few weeks.

Their sole Serie A defeat this term came at the hands of leaders Napoli, albeit Thiago Motta's men have drawn 13 league matches so far - effectively letting 17 points slip - and only sit fourth in the standings.

On Sunday evening, Juventus prevailed in a close-fought Derby d'Italia, with a late Francisco Conceicao strike seeing off Scudetto holders Inter Milan and bringing up three league wins on the spin for the first time in a year.

Juve could meet Inter again in the Champions League's last 16 - Arsenal are their other potential opponents - but first they must finish the job against PSV.

PSV are not only unable to call upon Ricardo Pepi, who has been ruled out for the remainder of the campaign with a serious knee injury, but fellow Americans Sergino Dest and Malik Tillman are also long-term absentees.

Furthermore, full-backs Rick Karsdorp and Olivier Boscagli - the latter of whom has been sidelined since picking up a muscular injury against Liverpool - are unlikely to play either.

Mauro Junior, Richard Ledezma and Manchester United loanee Tyrell Malacia will therefore vie for selection again; meanwhile, top scorer Luuk de Jong leads the line up front.

With main marksman Dusan Vlahovic out of favour, Juve's attack should be led by Randal Kolo Muani. The France forward has scored five goals in as many games since joining on loan from Paris Saint-Germain, becoming the first man to net five in his first three Serie A appearances this century.

Never afraid to tinker - even with a winning team - Thiago Motta may make changes on Wednesday, with Manuel Locatelli, Kenan Yildiz and fit-again full-back Andrea Cambiaso fronting a queue for promotion from the bench.

Bremer, Juan Cabal and Arkadiusz Milik are all out of action for the long term, while Pierre Kalulu is still unavailable and Douglas Luiz continues to struggle with a thigh problem.

PSV Eindhoven possible starting lineup:

Benitez; Ledezma, Flamingo, Obispo, Junior; Schouten, Veerman; Bakayoko, Saibari, Perisic; De Jong

Juventus possible starting lineup:

Di Gregorio; Weah, Gatti, Veiga, Cambiaso; Thuram, Locatelli; Gonzalez, McKennie, Yildiz; Kolo Muani