Although Napoli playmaker Stanislav Lobotka and defensive rock Alessandro Buongiorno hope to return for the Serie A season finale - both having exacerbated existing injuries by coming back too early - it remains to be seen whether either will be sufficiently fit to start.

Juan Jesus is also set to make himself available after a layoff, but Antonio Conte could still keep faith with makeshift centre-back Mathias Olivera, who usually plays on the left.

If Lobotka cannot play 90 minutes, Billy Gilmour would be retained in central midfield, linking up with fellow Scotland star Scott McTominay, who has recorded seven goal involvements at the Maradona in 2025 so far.

Romelu Lukaku has played a direct role in nine goals at home this calendar year - the most of any Serie A player - and he should be supported by Giacomo Raspadori, with speedy winger David Neres being deployed as an impact sub.

While Lukaku leads the line for Napoli, Cagliari striker Roberto Piccoli reached double figures for the season last time out; fellow forward Leonardo Pavoletti - renowned for several 'super-sub' heroics in recent years - returns from suspension, bolstering Davide Nicola's options up front.

Zito Luvumbo (thigh) and Gianluca Gaetano (knee) are now sidelined by injury, opening an opportunity for either Pavoletti or Nicolas Viola to join Piccoli in the final third.

Meanwhile, Napoli loanee Elia Caprile - who swapped clubs with Simone Scuffet in January - will start in goal against his parent club.

Napoli possible starting lineup:

Meret; Di Lorenzo, Rrahmani, Olivera, Spinazzola; Politano, Anguissa, Gilmour, McTominay; Raspadori, Lukaku

Cagliari possible starting lineup:

Caprile; Zappa, Mina, Luperto; Zortea, Deiola, Makoumbou, Adopo, Augello; Viola; Piccoli