Rayo Vallecano will be without Randy Nteka and Abdul Mumin due to knee injuries, while Jonathan Montiel is out with a quadriceps issue.

Pathe Ciss is expected to return to the starting lineup after serving a one-match ban, but Isi Palazon will be suspended for accumulating yellow cards.

Striker Raul de Tomas is set to be included in the matchday squad after recovering from a minor injury that kept him out of the win over Las Palmas.

For the visitors, Real Betis manager Pellegrini cannot call upon the injured trio of Diego Llorente, Marc Roca, and Chimy Avila.

Hector Bellerin is also absent following a season-ending hamstring injury sustained in last week's extra-time victory over Fiorentina.

After making significant changes in their previous match, Pellegrini might opt to bring back Youssouf Sabaly, Ricardo Rodriguez, Johnny Cardoso, Isco, Antony, Pablo Fornals, and Cedric Bakambu.

Rayo Vallecano possible starting lineup:

Batalla; Ratiu, Lejeune, Hernandez, Chavarria; Ciss, Lopez; De Frutos, Diaz, Garcia; Embarba

Real Betis possible starting lineup:

Adrian; Sabaly, Bartra, Natan, Rodriguez; Cardoso, Lo Celso; Antony, Isco, Fornals; Bakambu