ESPN BET released point spreads on every NFL regular-season game this week, and only one team is currently favored in every game: the Buffalo Bills.

The Bills opened as favorites in each of their 17 regular-season games, including in their Week 1 Sunday night home opener against the Baltimore Ravens and their Week 9 matchup against the visiting Kansas City Chiefs. The Ravens and Chiefs opened as favorites in each of their other games.

Buffalo is favored by 12.5 points over the New Orleans Saints in Week 4, tied for the largest opening line on the board. The Ravens also are 12.5-point favorites over the Cleveland Browns in Week 2.

"The Bills are tied at the top of our power ratings (with the Ravens and Philadelphia Eagles) and have the highest win total on the board," Joey Feazel, NFL oddsmakers for Caesars Sportsbook, told ESPN. "They have the ability to take advantage of their simpler schedule and weaker division."

The Bills have attracted more bets to win the Super Bowl than any other team at ESPN BET following the release of the 2025 schedule.

Since 1978, 23 teams have gone on to be favored in every game of a regular season, while 28 teams have been underdogs in every game of a regular season during that span. At least one team has been an underdog in every game in each of the last six seasons. As of Wednesday, the New York Giants, Browns and Saints are each favored in just one game this season:

• Week 5: Giants -1.5 at Saints

• Week 14: Browns -1.5 vs. Titans

• Week 16: Saints -1.5 vs. Jets

"The Saints took a significant drop in ratings after Derek Carr announced his retirement," Feazel said. "[It] will be a significant drop in their ratings regardless of who is starting among Spencer Rattler, Tyler Shough or Jake Haener."

Feazel said the Saints, Titans and Browns are at the bottom of his power ratings.

The New England Patriots, who were the only team to be underdogs in each of their regular-season games last year, are favored in 11 of their 17 games this season -- despite a win total of 8.5.

The Patriots over 8.5 wins is the most popular win-total wager at ESPN BET since the release of the schedule. The Saints under 5.5 wins is the second-most popular bet.